List of the IMSUT projects

1. Infectious and allergic diseases

  1. 1-1. Prophylactic Approaches
    1. 1-1-1. Next generation vaccines against influenza
    2. 1-1-2. New intranasal vaccine against influenza
    3. 1-1-3. Ebola virus disease: Surveillance, prevention and control
    4. 1-1-4. Novel vaccines against herpesviruses
    5. 1-1-5. Rice-based mucosal vaccine `MucoRice', a cold-chain and needle/syringe free for the prevention and treatment of infectious diseases
    6. 1-1-6. Cationic nanogel-based nasal vaccine for prevention and control of respiratory infectious diseases
    7. 1-1-7. Novel vaccines acting on pathogen sensors
  2. 1-2. Therapeutic Approaches
    1. 1-2-1. Next generation antivirals against influenza
    2. 1-2-2. Control of human immunodeficiency virus (HIV) transcription
    3. 1-2-3. Novel antivirals against herpesviruses
    4. 1-2-4. Understanding of molecular mechanisms for atopic and non-atopic allergic disorders

2. Cancer

  1. 2-1. Development of innovative strategies for cancer diagnosis and therapy
    1. 2-1-1. Development of novel serum biomarkers for the early detection of cancer
    2. 2-1-2. Research to elucidate molecular mechanisms underlying tumor metastasis
    3. 2-1-3. Development of oncolytic virus therapy for cancer
    4. 2-1-4. Therapeutic cancer vaccine for preventing the recurrence of cancer
    5. 2-1-5. A novel T cell immunotherapy for cancer
    6. 2-1-6. Development of a new class of immunological check-point inhibitor
    7. 2-1-7. Development of an oncolytic HSV vector fully retargeted specifically to cell surface antigens
    8. 2-1-8. Development of innovative cancer therapies and prevention targeting elimination of senescent cells from aged human
    9. 2-1-9. Antibody engineering & small molecule screening based on biophysical techniques for cancer diagnosis and therapy
  2. 2-2. Brain tumor
    1. 2-2-1. Development of oncolytic virus therapy for brain tumors
  3. 2-3. Breast cancer
    1. 2-3-1. Development of novel therapeutic strategies for malignant breast cancer
    2. 2-3-2. Overcoming triple negative breast cancer via innovative therapy with RNAi and drug delivery system
  4. 2-4. Lung cancer
    1. 2-4-1. Establishment of novel therapeutic and diagnostic approaches to lung cancer
    2. 2-4-2. Development of novel tumor markers for the early detection of non-small cell lung cancer
  5. 2-5. Pancreatic cancer
    1. 2-5-1. Development of novel diagnostic and therapeutic reagents for pancreatic cancer
    2. 2-5-2. Overcoming pancreatic cancer via innovative therapy with RNAi and drug delivery system
  6. 2-7. Hematological malignancies
    1. 2-7-1. Development of a cell-based oncolytic vaccinia virus therapy targeting hematological malignancies
    2. 2-7-2. Clinical trial to assess safety and efficacy of a novel cord blood stem cell transplantation method for hematopoietic malignancies

3. Genome medicine

  1. 3-1. Big data analysis
    1. 3-1-1. Hacking your cancer with big data by artificial intelligence and supercomputer - We are no more "a big fish in a little barrel"
    2. 3-1-2. Development of diagnostic and therapeutic tools for common disease including solid cancer by genome analyses
    3. 3-1-3. Genome-based drug and diagnostic tool development in blood disorders
    4. 3-1-4. Grassroots movement for genome medicine -Genome in your life-
    5. 3-1-5. Cancer precision medicine in Japan and in the US
  2. 3-2. Genome-editing technology
    1. 3-2-1. Development of novel Genome-editing technology using CRISPR/Cas9 system

4. Regenerative medicine, cell therapy, and stem cell research

  1. 4-1. Stem cell, iPS cell, disease model, repair, immuno-modulation
    1. 4-1-1. Human disease-modeling using iPS cell technologies
    2. 4-1-2. Immuno-regenerative medicine using mesenchymal stem cells for the treatment of graft-versus-host disease and encephalopathies
    3. 4-1-3. Novel therapies to control blood vessel formation: tissue engineering, stem cell expansion, and cancer

5. Neurological and neuromuscular diseases

  1. 5-1. muscle atrophy / sarcopenia / Amyotrophic lateral sclerosis
    1. 5-1-1. A novel therapeutic approach for ALS, sarcopenia, or related neuromuscular disorders aimed at protecting neuromuscular junctions (NMJs), based on the pathophysiological mechanisms underlying NMJ defects
    2. 5-1-2. Novel approach for targeting muscle atrophy and sarcopenia and metabolic syndrome
  2. 5-2. Psychiatric and neurological diseases
    1. 5-2-1. Comprehensive understanding of synaptic transmission and plasticity in the central nervous system, the higher brain function, such as learning/memory and emotion, and the mechanisms of etiology of psychiatrical and neurological disorders